Sometimes it's helpful to start with an empty canvas. Creating a blank template in Template Designer let's you do just that!
Navigate to Mailings Designer 2.0 > Templates
The Template Designer opens. Navigate to the Template Gallery tab.
Click the Blank Canvas thumbnail icon.
The Design window opens. Here, you can begin applying layouts to your design.
Starting from Square One
While having a basic design in mind is often a great starting point, sometimes it makes perfect sense to "go back to the drawing board" and start from scratch. Plus, by experimenting with a blank canvas, you'll learn a lot about how you like to work with Template Designer!